Katherine Austin Lathrop , 1915 – 2005

  • Al CNL, CNL 207 Bi DOE CNL Be DOE, +6 authors S CNL
  • Published 2005

Abstract

T he breakneck rate of change to which we have become accustomed in the scientific world has not been reflected in the number of changes in available radionuclides and radiopharmaceuticals between my last compilation in 2003 (J Nucl Med. 2003;44[6]:27N– 31N) and the current lists. Economic and regulatory issues have not kept pace with radiopharmaceutical science. Gone is radiolabeled hippuran (labeled with 123I or 131I), a stalwart of renal diagnosis since 1961, because of the excellent physical and biologic properties of 99mTcmertiatide (MAG3). 99mTc-lidofenin has disappeared as a hepatobiliary agent, leaving 99mTc-labeled disofenin and mebrofenin on the market. 131I-tositumomab finally passed U.S. Food and Drug Administration (FDA) review as another labeled antibody against lymphocyte antigen CD20 (as is 90Y-ibritumomab tiuxetan) for the therapy of lymphoma. 99mTcfanolesomab, an antibody directed against granulocyte antigen CD15, has been approved by the FDA for the diagnosis of appendicitis in patients age 5 and over with equivocal symptoms and signs. Although PET agents such as 11C-carbon monoxide, 11 C-flumenazil, 11C-mespiperone, 11C-methionine, 11Craclopride, 11C-acetate, 18F-fluorodopa, 13N-ammonia, and 15O-water are now being compounded under the stateregulated practice of medicine and pharmacy, these are not widely available outside of certain research institutions and so do not appear on the list. I have added 2 radiopharmaceuticals classified as “devices” for brachytherapy by the FDA: 90Y-microspheres (for unresectable hepatocellular carcinoma) and 125I-3iodo-4-hydroxybenzenesulfonate (for recurrent malignant glioma). A number of new radionuclides appear on this list, such as 7Be, 32Si, and 44Ti, produced by the U.S. Department of Energy (DOE), as well as the radioisotopes of plutonium, uranium, and thorium available from the (Continued on page 14N)

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Cite this paper

@inproceedings{CNL2005KatherineAL, title={Katherine Austin Lathrop , 1915 – 2005}, author={Al CNL and CNL 207 Bi DOE CNL Be DOE and C T Doe and Ce CNL and Cf DOE and CNL 248 Cm DOE Cm DOE and CNL 60 Cu INIS and C Wu and S CNL}, year={2005} }