Katanin knockdown supports a role for microtubule severing in release of basal bodies before mitosis in Chlamydomonas.

@article{Rasi2009KataninKS,
  title={Katanin knockdown supports a role for microtubule severing in release of basal bodies before mitosis in Chlamydomonas.},
  author={M Qasim Rasi and Jeremy David Kirk Parker and Jessica L Feldman and Wallace F. Marshall and Lynne M Quarmby},
  journal={Molecular biology of the cell},
  year={2009},
  volume={20 1},
  pages={
          379-88
        }
}
Katanin is a microtubule-severing protein that participates in the regulation of cell cycle progression and in ciliary disassembly, but its precise role is not known for either activity. Our data suggest that in Chlamydomonas, katanin severs doublet microtubules at the proximal end of the flagellar transition zone, allowing disengagement of the basal body from the flagellum before mitosis. Using an RNA interference approach we have discovered that severe knockdown of the p60 subunit of katanin… CONTINUE READING

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J. D. Parker, L. M. Quarmby
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