Kashin-Beck disease--expanding the spectrum of iodine-deficiency disorders.

  title={Kashin-Beck disease--expanding the spectrum of iodine-deficiency disorders.},
  author={Robert D. Utiger},
  journal={The New England journal of medicine},
  volume={339 16},
  • R. Utiger
  • Published 15 October 1998
  • Biology, Medicine
  • The New England journal of medicine
Selenium, as selenocysteine, is an integral component of two important enzymes — glutathione peroxidase and iodothyronine deiodinase — that are present in many tissues, including the thyroid gland.... 

Selenium, deiodinases and endocrine function.

Thyroid follicular cells maintain a highly oxidative environment as required for thyroid hormone synthesis, and Glutathione peroxidase expression in the thyroid gland is thus important to prevent oxidation-induced cellular toxicity.

The effect of Kashin‐Beck disease‐affected feed and T‐2 toxin on the bone development of Wistar rats

To investigate the effect of Kashin‐Beck disease (KBD)‐affected feed and T‐2 toxin on the bone development of Wistar rats, a large number of animals were fitted with KBD-affected feeding regimens.

Nutrition and Nutritional Supplements and Osteoarthritis

• There are numerous mechanisms by which micronutrients might be expected to influence the development or progression of osteoarthritis, but there has been insufficient research to draw definitive

Is There a Therapeutic Role for Selenium in Alpha-1 Antitrypsin Deficiency?

Together these ER stress-relieving and anti-inflammatory properties suggest a therapeutic potential for selenium supplementation in genetic emphysema.

Selenium deficiency and human disease

The beneficial role of selenium became apparent in the 1950’s, when it was shown to prevent a variety of diseases in animals, often when these animals were already exhibiting vitamin E deficiency. In

Rare Osteoarthritis: Ochronosis and Kashin-Beck Disease

Alkaptonuria accounts for reports of dark urine, including urine “as black as ink,” dating as far back as the Middle Ages, which demonstrates that this disorder has afflicted humans since ancient times.

Fulminant Heart Failure Due to Selenium Deficiency Cardiomyopathy (Keshan Disease)

A case of fulminant heart failure in a middle aged woman with a complex medical and surgical history including documented malabsorption and selenium deficiency is presented.

Selenium Status after Roux-en-Y Gastric Bypass: Interventions and Recommendations

The evidence regarding selenium deficiency in RYGB patients, as well its nutritional treatment methods are examined, ranging from 2006 to 2017.

Effect of oral iodized oil on thyroid size and thyroid hormone metabolism in children with concurrent selenium and iodine deficiency

Although more severe Se deficiency partially blunts the thyroid response to iodine supplementation, oral iodized oil is an effective method for iodine repletion in goitrous children who are Se deficient.

The Prevention Effect of Selenium on Prevalence of Children Kaschin-Beck Disease in Active Endemic Areas in Qinghai Plateau

There was a close relationship between selenium content and prevalence of KBD, so it is very necessary to supplement seenium appropriately for KBD prevention.



The epidemiology of selenium deficiency in the etiological study of endemic diseases in China.

  • K. GeG. Yang
  • Medicine
    The American journal of clinical nutrition
  • 1993
The epidemiology of selenium deficiency in China is reviewed in connection with the etiology of human seenium-responsive diseases, the well-defined Keshan disease (KD) and the less-well-defined Kashin-Beck disease (BBD).

Selenium and the thyroid: how the relationship was established.

Selenium deficiency may protect against iodine deficiency by decreasing T4 metabolism--and thus iodide leakage and--perhaps also by increasing H2O2 supply and thyroid hormone synthesis and thus thyroid efficiency.

Goitrogens in food and water.

  • E. Gaitan
  • Medicine
    Annual review of nutrition
  • 1990
Malnutrition and poor socioeconomic conditions, as for iodine deficiency, enhance the action of environmental goitrogens, and a coordinated multidisciplinary approach is essential to solving this public health problem.

Kashin-Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status.

In areas where severe selenium deficiency is endemic, iodine deficiency is a risk factor for Kashin-Beck disease and low urinary iodine, high serum thyrotropin, and low serum thyroxine-binding globulin values were associated with an increased risk of Kashin -Beck disease, but a low serum seenium concentration was not.

The epidemiology of iodine-deficiency diseases in China.

Iodine-deficiency diseases (IDDs) are wide-spread in China, distributed mainly in the inland and mountainous regions and can be very severe in areas where selenium status is thought to be adequate.

Iodine and selenium deficiency associated with cretinism in northern Zaire.

This combined iodine and selenium deficiency could be associated with the elevated frequency of endemic myxedematous cretinism in Central Africa.

Endemic cretinism: toward a unifying hypothesis.

  • S. BoyagesJ. Halpern
  • Medicine, Biology
    Thyroid : official journal of the American Thyroid Association
  • 1993
The hypothesis states that the clinical expression of endemic cretinism is determined by the sum of two pathophysiologic processes; the first process is fetal hypothyroidism which results in the neurological damage of the disorder and the second process is the duration and magnitude of postnatal hypothyrogenism which dictates the final clinical appearance.

A comparative study of neurological and myxedematous endemic cretinism in western China.

Categorization of the cretins into the conventional types did not reflect the pathophysiology of the condition, since an identical pattern and intensity of neurological, intellectual, and audiometric deficits were common to and equally present in all three types of endemic cretin regardless of their thyroid function.

Studies on human dietary requirements and safe range of dietary intakes of selenium in China and their application in the prevention of related endemic diseases.

600 and 400 micrograms/d were suggested as the individual daily maximum safe selenium intake and the safe dietary selenum intake, respectively, in the prevention of Se-related endemic KD and Kashin-Beck disease.