Karyotypic instability and centrosome aberrations in the progeny of finite life-span human mammary epithelial cells exposed to sparsely or densely ionizing radiation.

@article{Sudo2008KaryotypicIA,
  title={Karyotypic instability and centrosome aberrations in the progeny of finite life-span human mammary epithelial cells exposed to sparsely or densely ionizing radiation.},
  author={Hiroko Sudo and James C. Garbe and Martha R. Stampfer and Mary Helen Barcellos-Hoff and Andmitchell Kronenberg},
  journal={Radiation research},
  year={2008},
  volume={170 1},
  pages={
          23-32
        }
}
The human breast is sensitive to radiation carcinogenesis, and genomic instability occurs early in breast cancer development. This study tests the hypothesis that ionizing radiation elicits genomic instability in finite life-span human mammary epithelial cells (HMEC) and asks whether densely ionizing radiation is a more potent inducer of instability. HMEC in a non-proliferative state were exposed to X rays or 1 GeV/nucleon iron ions followed by delayed plating. Karyotypic instability and… CONTINUE READING
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