Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial.

@article{Moorman2007KaryotypeIA,
  title={Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial.},
  author={Anthony V. Moorman and Christine J. Harrison and Georgina Buck and S. M. Richards and Lorna M. Secker-Walker and Mary Martineau and Gail H Vance and Athena M Cherry and Rodney R. Higgins and Adele K. Fielding and Letizia Foroni and Elisabeth Paietta and Martin S. Tallman and Mark R. Litzow and Peter H Wiernik and Jacob M. Rowe and Anthony H. Goldstone and Gordon W. Dewald},
  journal={Blood},
  year={2007},
  volume={109 8},
  pages={
          3189-97
        }
}
Pretreatment cytogenetics is a known predictor of outcome in hematologic malignancies. However, its usefulness in adult acute lymphoblastic leukemia (ALL) is generally limited to the presence of the Philadelphia (Ph) chromosome because of the low incidence of other recurrent abnormalities. We present centrally reviewed cytogenetic data from 1522 adult patients enrolled on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial. The incidence and clinical… 

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