Karyotype alteration generates the neoplastic phenotypes of SV40-infected human and rodent cells

@inproceedings{Bloomfield2015KaryotypeAG,
  title={Karyotype alteration generates the neoplastic phenotypes of SV40-infected human and rodent cells},
  author={Mathew Bloomfield and Peter H. Duesberg},
  booktitle={Molecular Cytogenetics},
  year={2015}
}
Despite over 50 years of research, it remains unclear how the DNA tumor viruses SV40 and Polyoma cause cancers. Prevailing theories hold that virus-coded Tumor (T)-antigens cause cancer by inactivating cellular tumor suppressor genes. But these theories don’t explain four characteristics of viral carcinogenesis: (1) less than one in 10,000 infected cells become cancer cells, (2) cancers have complex individual phenotypes and transcriptomes, (3) recurrent tumors without viral DNA and proteins… CONTINUE READING
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Cold Spring Harbor Laboratorty; 1973

  • Tooze J. The Molecular Biology of Tumour Viruses. Cold S Harbor
  • Bloomfield and Duesberg Molecular Cytogenetics
  • 2015
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