Karyopherin alpha 2 (KPNA2) is associated with the natural resistance to Schistosoma japanicum infection in Microtus fortis.

@article{Cheng2011KaryopherinA2,
  title={Karyopherin alpha 2 (KPNA2) is associated with the natural resistance to Schistosoma japanicum infection in Microtus fortis.},
  author={Gang Cheng and Qiang Gong and Nan Gai and De-hui Xiong and Yuan-jing Yu and Qingren Zeng and Wei-xin Hu},
  journal={Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year={2011},
  volume={65 3},
  pages={
          230-7
        }
}
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Genome assembly and transcriptome analysis provide insights into the antischistosome mechanism of Microtus fortis.
Genome assembly and transcriptome analysis provide insights into the anti-schistosome mechanism of Microtus fortis
TLDR
The first de novo genome assembly of M. fortis is performed, performing comprehensive gene annotation and evolution analysis, and it is revealed that intense immune response occurred in mouse in late stages of infection (28~42 days post infection), and cannot eliminate schistosome.
De novo assembly and transcriptome characterization: novel insights into the natural resistance mechanisms of Microtus fortis against Schistosoma japonicum
TLDR
Gene ontology terms and pathways related to the DEGs revealed that up-regulated transcripts were involved in metabolism, immunity and inflammatory responses, and demonstrated that natural and adaptive immune responses, play an important role in M. fortis immunity to S. japonicum.
Transcriptional profiling of Microtus fortis responses to S. japonicum: New sight into Mf‐Hsp90α resistance mechanism
TLDR
RNA‐Seq was conducted to obtain the transcriptome profile of M. fortis liver infected with S. japonicum at different time points to investigate the mechanism of anti‐schistosome effect of Mf‐HSP90α.
High throughput data analyses of the immune characteristics of Microtus fortis infected with Schistosoma japonicum
TLDR
Elevated expression of metabolites and pathways involved in histidine metabolism, valine, leucine, and isoleucine biosyntheses, and lysine degradation may promote the phagocytic function of the neutrophils and natural killer cell activity following TLR activation.
A Microtus fortis protein, serum albumin, is a novel inhibitor of Schistosoma japonicum schistosomula
TLDR
The data indicate the potential of Mf -albumin as one of the major selective forces for schistosomiasis.
Mechanisms of Resistance to Schistosoma japonicum Infection in Microtus fortis, the Natural Non-permissive Host
TLDR
This review presents an overview of the established and purported mechanisms of resistance to S. japonicum infection in M. fortis in comparison to Rattus norvegicus, a semi-permissive host.
Effects of Microtus fortis lymphocytes on Schistosoma japonicum in a bone marrow transplantation model.
A longitudinal study reveals the alterations of the Microtus fortis colonic microbiota during the natural resistance to Schistosoma japonicum infection.
Bridging HIV-1 Cellular Latency and Clinical Long-Term Non-Progressor: An Interactomic View
TLDR
Comp comparative insights into HIV-1 latency are offered, which will facilitate the understanding of the genetic basis of HIV- 1 latency in vivo and serve as a clue for future treatment dealing with key targets in HIV-2 latency.
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References

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TLDR
It can be concluded that the method which may lay foundation to clone resistance associated gene and to reveal the resistance mechanism of Microtus fortis to Schistosoma japonicum infection is concluded.
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Investigation of the immunological characteristics of natural resistance to Schistosoma japonicum infection in Microtus fortis (MF) living in the Dongting Lake area found no significant difference between WMF and BMF.
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The higher degree of egg reduction rate in the test group suggested that SjSDISP vaccine may primarily play a role in anti-embryonation or anti-fecundity immunity, and suggest that it may be a novel and partially protective vaccine candidate against schistosomiasis.
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TLDR
The schistosomula-killing effect of the serum of MF was stronger than that of mice, and it was the same with the tissues/organs of MF.
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Natural antibodies in Microtus fortis react with antigens derived from four stages in the life-cycle of Schistosoma japonicum.
TLDR
The observations indicate that even uninfected M. fortis produce antibodies which react with S. japonicum, and this presumably results in the natural resistance to infection which has been reported in these rodents.
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