Karyomegaly and intranuclear inclusions in the renal tubules of sentinel ICR mice (mus musculus).

@article{Baze2006KaryomegalyAI,
  title={Karyomegaly and intranuclear inclusions in the renal tubules of sentinel ICR mice (mus musculus).},
  author={Wallace B. Baze and Thomas J Steinbach and Michelle L Fleetwood and Terrell W Blanchard and Kirstin F. Barnhart and Mark J. McArthur},
  journal={Comparative medicine},
  year={2006},
  volume={56 5},
  pages={435-8}
}
Among 585 sentinel ICR mice (Mus musculus), 8 (7 female, 1 male) had unusual microscopic lesions in the kidney. Light microscopy revealed occasional tubular epithelial cells with large, karyomegalic nuclei that contained intranuclear inclusions and marginated chromatin. These cells were randomly present in the cortex and medulla but were more prominent near the corticomedullary junc tion. Rare pyknotic cells and mild interstitial infiltrates of lymphocytes and plasma cells were associated with… CONTINUE READING