Kappa-selective agonists decrease postsynaptic potentials and calcium components of action potentials in the supraoptic nucleus of rat hypothalamus in vitro 

@article{Inenaga1994KappaselectiveAD,
  title={Kappa-selective agonists decrease postsynaptic potentials and calcium components of action potentials in the supraoptic nucleus of rat hypothalamus in vitro
},
  author={Kiyotoshi Inenaga and T. Nagatomo and Kazuki Nakao and Noboru Yanaihara and H. Yamashita},
  journal={Neuroscience},
  year={1994},
  volume={58},
  pages={331-340}
}
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Selective modulation of excitatory transmission by mu-opioid receptor activation in rat supraoptic neurons.
TLDR
Results indicate that mu-opioid receptor activation selectively inhibits excitatory activity in SON neurons via a presynaptic mechanism.
Inhibition of rat oxytocin and vasopressin supraoptic nucleus neurons by nociceptin in vitro
Opioidergic modulation of voltage-activated K+ currents in magnocellular neurons of the supraoptic nucleus in rat.
Opioidergic modulation plays an important role in the control of oxytocin and vasopressin release by magnocellular neurons (MCNs) in the supraoptic and paraventricular nuclei of the hypothalamus. We…
κ-Opioid Regulation of Neuronal Activity in the Rat Supraoptic Nucleus In Vivo
TLDR
Normally functioning κ-opioid mechanisms on vasopressin cells are essential for the expression of phasic firing.
Increased synaptic activity in magnocellular neurons of supraoptic nucleus and plasma vasopressin levels due to acute administration of morphine in male rats
TLDR
It is suggested that acute administration of morphine stimulates the MCNs and AVP secretion in rats and produces an increase in sEPSCs and a decrease in sIPSCs frequencies.
κ‐Opioid Receptor Activation Inhibits Post‐Spike Depolarizing After‐Potentials in Rat Supraoptic Nucleus Neurones In Vitro
TLDR
κ‐opioid receptor activation reduces depolarizing after‐potential amplitude in supraoptic nucleus cells and this may underlie the reduction in burst duration of vasopressin cells caused by an endogenous κ‐agonist in vivo.
The mechanism of inhibitory actions of propofol on rat supraoptic neurons.
TLDR
Propofol inhibits somatodendritic arginine vasopressin release from the supraoptic nucleus, and the enhancement of GABAergic inhibitory synaptic inputs and the inhibition of voltage-gated Ca2+ entry are involved in the inhibition.
Local opioid inhibition and morphine dependence of supraoptic nucleus oxytocin neurones in the rat in vivo
TLDR
The acute inhibition of supraoptic nucleus oxytocin neurones which results from systemic administration of opioid agonists primarily occurs within the supraopti nucleus itself, since the antagonist naloxone was effective when given into the supraOptic nucleus.
Effects of opioid peptides on the electrical activity of preoptic and hypothalamic neurons in the quail brain.
TLDR
There are functional opiate receptors in subsets of preoptic/hypothalamic neurons and that one of their main physiological functions in these areas is an inhibition of neuronal activities, which suggests that some reproductive behavior may be regulated through the mechanism that provokes such an inhibition.
Renal responses produced by microinjection of the kappa opioid receptor agonist, U50-488H, into sites within the rat lamina terminalis
TLDR
The ability of U50 to increase V without affecting sodium excretion and RSNA raises the possibility that LT neurons could be an important substrate through which drugs targeting KOR could selectively facilitate water excretion in sodium‐retaining diseases such as congestive heart failure.
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References

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Direct effects of an opioid peptide selective for μ-receptors: Intracellular recordings in the paraventricular and supraoptic nuclei of the guinea-pig
Activation of κ-opioid receptors depresses electrically evoked excitatory postsynaptic potentials on 5-HT-sensitive neurones in the rat dorsal raphé nucleus in vitro
Effects of excitatory amino acid antagonists on synaptic responses of supraoptic neurons in slices of rat hypothalamus.
1. Intracellular recordings from magnocellular neurons in the supraoptic nucleus (SON) were obtained from rat hypothalamic slices to determine the effects of specific transmitter antagonists on…
Kappa‐Selective Opioid Receptor Agonists Leumorphin and Dynorphin Inhibit Supraoptic Neurons in Rat Hypothalamic Slice Preparations
TLDR
The results suggest that LM acts at the same receptors as dynorphin, and that opioids acting preferentially at kappa‐receptors inhibit both vasopressin and oxytocin neurons while delta‐ and mu‐receptor agonists inhibit primarily oxytoc in neurons.
Effect of opioid peptides on the paraventricular nucleus of the guinea pig hypothalamus is mediated by μ-type receptors
U-50,488H inhibits dynorphin and glutamate release from guinea pig hippocampal mossy fiber terminals
Bicuculline blocks an inhibitory baroreflex input to supraoptic vasopressin neurons.
TLDR
It is suggested that gamma-aminobutyric acidA receptors mediate the depressant responses observed among supraoptic vasopressin-secreting neurons consequent to peripheral baroreceptor activation.
Ionic currents in cultured supraoptic neurons: Actions of peptides and transmitters
Effects of morphine and d-Ala, d-Leu enkephalin on the electrical activity of supraoptic neurosecretory cells in vitro
Dynorphin reduces calcium-dependent action potential duration by decreasing voltage-dependent calcium conductance
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