Kappa-opioid receptors on astrocytes stimulate L-type Ca2+ channels.

  title={Kappa-opioid receptors on astrocytes stimulate L-type Ca2+ channels.},
  author={Peter S. Eriksson and Michael J Nilsson and Maria W{\aa}gberg and Elisabeth Hansson and Lars R{\"o}nnb{\"a}ck},
  volume={54 2},
Cultured astrocytes from the cerebral cortex of the rat respond to opioid kappa-receptor stimulation with a substantial elevation of the cytoplasmic free calcium, visualized through the use of the fluorescent calcium indicator Fura-2. The stimulation of kappa-receptors with U-50488H increases the level of calcium through a dose-related stimulatory effect on the transmembrane calcium influx. The kappa-receptor stimulation was completely blocked by the selective kappa-receptor blocker nor… CONTINUE READING


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