Kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouse

@article{Fantegrossi2005KappaopioidRE,
  title={Kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouse},
  author={W. Fantegrossi and Kelly M Kugle and Leander J. Valdes and Masato Koreeda and James H. Woods},
  journal={Behavioural Pharmacology},
  year={2005},
  volume={16},
  pages={627-633}
}
Salvinorin A is a pharmacologically active diterpene that occurs naturally in the Mexican mint Ska Maria Pastora (Salvia divinorum) and represents the first naturally occurring κ-opioid receptor agonist. The chemical structure of salvinorin A is novel among the opioids, and thus defines a new structural class of κ-opioid-receptor selective drugs. Few studies have examined the effects of salvinorin A in vivo, and fewer still have attempted to assess the agonist actions of this compound at… 
Unconditioned Behavioral Effects of the Powerful κ-Opioid Hallucinogen Salvinorin A in Nonhuman Primates: Fast Onset and Entry into Cerebrospinal Fluid
TLDR
These are the first studies documenting rapid unconditioned effects of salvinorin A in a primate species, consistent with descriptive reports of rapid and robust effects of this powerful hallucinogen in humans.
Effects of Salvinorin A, a κ-Opioid Hallucinogen, on a Neuroendocrine Biomarker Assay in Nonhuman Primates with High κ-Receptor Homology to Humans
TLDR
It is indicated that the hallucinogen salvinorin A acts as a high-efficacy κ-agonist in nonhuman primates in a translationally viable neuroendocrine biomarker assay, including particular C-terminal residues thought to be involved in receptor desensitization and internalization.
Synthesis and κ-Opioid Receptor Activity of Furan-Substituted Salvinorin A Analogues
TLDR
The synthesis of several salvinorin A derivatives with modified furan rings successfully reduced drug-seeking behavior in an animal model of drug-relapse without producing the sedation observed with other κ-opioid agonists.
The antinociceptive effect of salvinorin A in mice.
A single injection of a novel kappa opioid receptor agonist salvinorin A attenuates the expression of cocaine-induced behavioral sensitization in rats
TLDR
It is indicated that Sal A, just like traditional KOPr agonists, attenuates cocaine-induced behavioral sensitization but does not produce the adverse effect of conditioned aversion, suggesting improved potential compliance.
Comparison of the discriminative stimulus effects of salvinorin A and its derivatives to U69,593 and U50,488 in rats
TLDR
These findings support previous reports indicating that the discriminative stimulus effects of salvinorin A are mediated by kappa receptors, and future studies may assist in the development and screening of salvinegorin A analogs for potential pharmacotherapy.
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TLDR
The naturally occurring hallucinogen salvinorin A produces discriminative stimulus effects similar to those of a high efficacy κ-agonist in non-human primates.
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TLDR
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Salvinorin A is the first naturally occurring nonnitrogenous opioid-receptor subtype-selective agonist for kappa opioid receptors, and may represent novel psychotherapeutic compounds for diseases manifested by perceptual distortions (e.g., schizophrenia, dementia, and bipolar disorders).
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    Proceedings of the National Academy of Sciences of the United States of America
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TLDR
Salvinorin A is the first naturally occurring nonnitrogenous opioid-receptor subtype-selective agonist for κ opioid receptors and may represent novel psychotherapeutic compounds for diseases manifested by perceptual distortions (e.g., schizophrenia, dementia, and bipolar disorders).
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TLDR
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TLDR
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