Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses.

Abstract

Previous studies have demonstrated that stress may increase prodynorphin gene expression, and kappa opioid agonists suppress drug reward. Therefore, we tested the hypothesis that stress-induced release of endogenous dynorphin may mediate behavioral responses to stress and oppose the rewarding effects of cocaine. C57Bl/6 mice subjected to repeated forced… (More)

Topics

7 Figures and Tables

Cite this paper

@article{McLaughlin2003KappaOR, title={Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses.}, author={Jay P. McLaughlin and Monica Marton-Popovici and Charles C. Chavkin}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={2003}, volume={23 13}, pages={5674-83} }