Kappa opioid agonists produce anxiolytic-like behavior on the elevated plus-maze

@article{Privette2005KappaOA,
  title={Kappa opioid agonists produce anxiolytic-like behavior on the elevated plus-maze},
  author={Thomas H. Privette and David M. Terrian},
  journal={Psychopharmacology},
  year={2005},
  volume={118},
  pages={444-450}
}
The selectivek agonist U-50,488H was evaluated on the elevated plus-maze test of anxiety. U-50,488H was administered intraperitoneally to male Sprague-Dawley rats 20 min before testing, first in an open field apparatus, then followed immediately on the elevated plus-maze. No significant change in spontaneous locomotor activity was measured in the open field apparatus, suggesting that U-50,488H was devoid of sedative effects in the dose range tested (0.1–1000 µg/kg, IP). Doses between 10 and… 
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