Kappa Opioid Receptors Regulate Stress-Induced Cocaine Seeking and Synaptic Plasticity

@article{Graziane2013KappaOR,
  title={Kappa Opioid Receptors Regulate Stress-Induced Cocaine Seeking and Synaptic Plasticity},
  author={Nicholas M. Graziane and Abigail M Polter and Lisa A Briand and R. Christopher Pierce and Julie A Kauer},
  journal={Neuron},
  year={2013},
  volume={77},
  pages={942-954}
}
Stress facilitates reinstatement of addictive drug seeking in animals and promotes relapse in humans. Acute stress has marked and long-lasting effects on plasticity at both inhibitory and excitatory synapses on dopamine neurons in the ventral tegmental area (VTA), a key region necessary for drug reinforcement. Stress blocks long-term potentiation at GABAergic synapses on dopamine neurons in the VTA (LTPGABA), potentially removing a normal brake on activity. Here we show that blocking kappa… CONTINUE READING
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