Kappa Opioid Receptors Regulate Stress-Induced Cocaine Seeking and Synaptic Plasticity


Stress facilitates reinstatement of addictive drug seeking in animals and promotes relapse in humans. Acute stress has marked and long-lasting effects on plasticity at both inhibitory and excitatory synapses on dopamine neurons in the ventral tegmental area (VTA), a key region necessary for drug reinforcement. Stress blocks long-term potentiation at… (More)
DOI: 10.1016/j.neuron.2012.12.034


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