Kaposi sarcoma herpesvirus microRNA function in lymphatic endothelial cells

@inproceedings{Hansen2010KaposiSH,
  title={Kaposi sarcoma herpesvirus microRNA function in lymphatic endothelial cells},
  author={Annika Hansen},
  year={2010}
}
Kaposi’s sarcoma herpesvirus (KSHV) is the causative agent of Kaposi’s sarcoma (KS), the most common AIDS-associated malignancy. KS lesions are comprised of poorly differentiated, spindle-shaped endothelial cells, the precursors of which are lymphatic endothelial cells (LEC). KSHV infection of LEC induces transcriptional reprogramming towards a phenotype more analogous to blood vessel endothelial cells BEC. KSHV encodes 17 mature miRNAs (miRNA), 14 of which are co-expressed as a cluster… CONTINUE READING

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