Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4/K10) is a novel interaction partner of CSL/CBF1, the major downstream effector of Notch signaling.

@article{Heinzelmann2010KaposisSH,
  title={Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4/K10) is a novel interaction partner of CSL/CBF1, the major downstream effector of Notch signaling.},
  author={Katharina Heinzelmann and Barbara A. Scholz and Agnes Nowak and Even Fossum and Elisabeth Kremmer and Juergen Haas and Ronald M Frank and Bettina Kempkes},
  journal={Journal of virology},
  year={2010},
  volume={84 23},
  pages={12255-64}
}
In cells infected with the Kaposi's sarcoma-associated herpesvirus (KSHV), CSL/CBF1 signaling is essential for viral replication and promotes the survival of KSHV-infected cells. CSL/CBF1 is a DNA adaptor molecule which recruits coactivator and corepressor complexes to regulate viral and cellular gene transcription and which is a major downstream effector molecule of activated Notch. The interaction of KSHV RTA and LANA with CSL/CBF1 has been shown to balance the lytic and latent viral life… CONTINUE READING