Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via AP-1 and Ets1.

@article{Ye2007KaposisSH,
  title={Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via AP-1 and Ets1.},
  author={Feng-chun Ye and David J. Blackbourn and Michael 4 Mengel and Jian-ping Xie and Li-Wu Qian and Whitney E. Greene and I J Yeh and David Graham and Shou-Jiang Gao},
  journal={Journal of virology},
  year={2007},
  volume={81 8},
  pages={3980-91}
}
Infection by Kaposi's sarcoma-associated herpesvirus (KSHV) is required for the development of Kaposi's sarcoma (KS), a highly inflammatory angiogenic tumor of endothelial cells commonly found in untreated AIDS patients. Angiopoietin 2 (Ang-2) modulates the vasculature during inflammation and angiogenesis, but the mechanism by which KSHV regulates Ang-2 expression has not been investigated. Here, we show that KSHV infection of primary human umbilical vein endothelial cells induced the… CONTINUE READING

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