Kaposi's sarcoma-associated herpesvirus-induced upregulation of the c-kit proto-oncogene, as identified by gene expression profiling, is essential for the transformation of endothelial cells.

@article{Moses2002KaposisSH,
  title={Kaposi's sarcoma-associated herpesvirus-induced upregulation of the c-kit proto-oncogene, as identified by gene expression profiling, is essential for the transformation of endothelial cells.},
  author={Ashlee V Moses and Michael A. Jarvis and Camilo M. Raggo and Yolanda C Bell and Rebecca A. Ruhl and B G Mattias Luukkonen and Diana J. Griffith and Cecily L Wait and Brian J. Druker and Michael C Heinrich and Jay A. Nelson and Klaus Fr{\"u}h},
  journal={Journal of virology},
  year={2002},
  volume={76 16},
  pages={8383-99}
}
Kaposi's sarcoma (KS), the most frequent malignancy afflicting AIDS patients, is characterized by spindle cell formation and vascularization. Infection with KS-associated herpesvirus (KSHV) is consistently observed in all forms of KS. Spindle cell formation can be replicated in vitro by infection of dermal microvascular endothelial cells (DMVEC) with KSHV. To study the molecular mechanism of this transformation, we compared RNA expression profiles of KSHV-infected and mock-infected DMVEC… CONTINUE READING