Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1

@inproceedings{Roy2009KankAA,
  title={Kank attenuates actin remodeling by preventing interaction between
IRSp53 and Rac1},
  author={Badal Chandra Roy and Naoto Kakinuma and Ryoiti Kiyama},
  booktitle={The Journal of cell biology},
  year={2009}
}
In this study, insulin receptor substrate (IRS) p53 is identified as a binding partner for Kank, a kidney ankyrin repeat-containing protein that functions to suppress cell proliferation and regulate the actin cytoskeleton. Kank specifically inhibits the binding of IRSp53 with active Rac1 (Rac1(G12V)) but not Cdc42 (cdc42(G12V)) and thus inhibits the IRSp53-dependent development of lamellipodia without affecting the formation of filopodia. Knockdown (KD) of Kank by RNA interference results in… CONTINUE READING

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