Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress.

@article{Yiu2016KallistatinPA,
  title={Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress.},
  author={Wai Han Yiu and Dickson W. L. Wong and Hao Wu and Rui Li and Irene Y. L. Yam and Loretta Y. Y. Chan and Joseph C K Leung and Hui Y Lan and Kar Neng Lai and Sydney C. W. Tang},
  journal={Kidney international},
  year={2016},
  volume={89 2},
  pages={386-98}
}
Kallistatin is a serine protease inhibitor with anti-inflammatory, anti-angiogenic, and anti-oxidative properties. Since oxidative stress plays a critical role in the pathogenesis of diabetic nephropathy, we studied the effect and mechanisms of action of kallistatin superinduction. Using ultrasound-microbubble-mediated gene transfer, kallistatin overexpression was induced in kidney tubules. In db/db mice, kallistatin overexpression reduced serum creatinine and BUN levels, ameliorated… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…