Kallistatin limits abdominal aortic aneurysm by attenuating generation of reactive oxygen species and apoptosis

  title={Kallistatin limits abdominal aortic aneurysm by attenuating generation of reactive oxygen species and apoptosis},
  author={Smriti Murali Krishna and Jiaze Li and Yutang Wang and Corey Stephen Moran and Alexandra F. Trollope and Pacific Huynh and Roby J. Jose and Erik Biros and Jian-xing Ma and Jonathan Golledge},
  journal={Scientific Reports},
Inflammation, vascular smooth muscle cell apoptosis and oxidative stress are believed to play important roles in abdominal aortic aneurysm (AAA) pathogenesis. Human kallistatin (KAL; gene SERPINA4) is a serine proteinase inhibitor previously shown to inhibit inflammation, apoptosis and oxidative stress. The aim of this study was to investigate the role of KAL in AAA through studies in experimental mouse models and patients. Serum KAL concentration was negatively associated with the diagnosis… 

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