Kallistatin inhibits TGF-β-induced endothelial-mesenchymal transition by differential regulation of microRNA-21 and eNOS expression.

@article{Guo2015KallistatinIT,
  title={Kallistatin inhibits TGF-β-induced endothelial-mesenchymal transition by differential regulation of microRNA-21 and eNOS expression.},
  author={Youming Guo and Pengfei Li and Grant Bledsoe and Zhi-rong Yang and Lee Chao and Julie Chao},
  journal={Experimental cell research},
  year={2015},
  volume={337 1},
  pages={
          103-10
        }
}
Kallistatin, an endogenous protein, consists of two structural elements: active site and heparin-binding domain. Kallistatin exerts beneficial effects on fibrosis by suppressing transforming growth factor (TGF)-β synthesis in animal models. TGF-β is the most potent inducer of endothelial-mesenchymal transition (EndMT), which contributes to fibrosis and cancer. MicroRNA (miR)-21 is an important player in organ fibrosis and tumor invasion. Here we investigated the potential role of kallistatin in… CONTINUE READING
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