Kallistatin attenuates endothelial apoptosis through inhibition of oxidative stress and activation of Akt-eNOS signaling.

@article{Shen2010KallistatinAE,
  title={Kallistatin attenuates endothelial apoptosis through inhibition of oxidative stress and activation of Akt-eNOS signaling.},
  author={Bo Shen and Lin Gao and Y. Z. Hsu and Grant Bledsoe and Makato Hagiwara and Lee Chao and Julie Chao},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2010},
  volume={299 5},
  pages={H1419-27}
}
Kallistatin is a regulator of vascular homeostasis capable of controlling a wide spectrum of biological actions in the cardiovascular and renal systems. We previously reported that kallistatin inhibited intracellular reactive oxygen species formation in cultured cardiac and renal cells. The present study was aimed to investigate the role and mechanisms of kallistatin in protection against oxidative stress-induced vascular injury and endothelial cell apoptosis. We found that kallistatin gene… CONTINUE READING

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