Kallikrein-related peptidase 7 promotes multicellular aggregation via the alpha(5)beta(1) integrin pathway and paclitaxel chemoresistance in serous epithelial ovarian carcinoma.

@article{Dong2010KallikreinrelatedP7,
  title={Kallikrein-related peptidase 7 promotes multicellular aggregation via the alpha(5)beta(1) integrin pathway and paclitaxel chemoresistance in serous epithelial ovarian carcinoma.},
  author={Ying Dong and Olivia L Tan and D Loessner and Carson Stephens and Carina M. Walpole and Glen M Boyle and Peter G Parsons and Judith Ann Clements},
  journal={Cancer research},
  year={2010},
  volume={70 7},
  pages={2624-33}
}
Kallikrein-related peptidase 7 (KLK7) is upregulated in epithelial ovarian carcinoma (EOC) with high levels correlated with poor prognosis. However, the mechanisms underlying this relationship and the role of KLK7 in EOC progression are unknown. We report that two different KLK7 transcripts, KLK7-253 and KLK7-181, are simultaneously expressed in high-grade serous EOC. Multicellular aggregates (MCA), which promote cell survival and chemoresistance, were observed in SKOV-3 cells stably… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 58 references

Response of human peritoneal mesothelial cells to inflammatory injury is regulated by interleukin-1beta and tumor necrosis factor-alpha.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society • 2006
View 11 Excerpts
Highly Influenced

Aberrant activation of the androgen receptor by NFκ B 2 / p 52 in prostate cancer cells

N Nadiminty, W Lou, +6 authors AC Gao
Cancer Res • 2010

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