Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice

Abstract

INTRODUCTION Memory loss and increased anxiety are clinical hallmarks of Alzheimer's disease (AD). Kallikrein-8 is a protease implicated in memory acquisition and anxiety, and its mRNA is known to be up-regulated in AD-affected human hippocampus. Therefore, an involvement of Kallikrein-8 in Alzheimer's pathogenesis is conceivable but remains to be proved… (More)
DOI: 10.1016/j.jalz.2016.05.006

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