Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis.

@article{Scarisbrick2012Kallikrein6R,
  title={Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis.},
  author={Isobel A Scarisbrick and Hyesook Yoon and Michael Panos and Nadya Larson and Sachiko I. Blaber and Michael Blaber and Moses Rodriguez},
  journal={Brain pathology},
  year={2012},
  volume={22 5},
  pages={709-22}
}
Kallikrein 6 (Klk6) is a secreted serine protease that is elevated in active multiple sclerosis lesions and patient sera. To further evaluate the involvement of Klk6 in chronic progressive demyelinating disease, we determined its expression in the brain and spinal cord of SJL mice infected with Theiler's murine encephalomyelitis virus (TMEV) and assessed the effects of Klk6-neutralizing antibodies on disease progression. Klk6 RNA expression was elevated in the brain and spinal cord by 7 days… CONTINUE READING

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