Kallidinogenase normalizes retinal vasopermeability in streptozotocin-induced diabetic rats: potential roles of vascular endothelial growth factor and nitric oxide.

@article{Kato2009KallidinogenaseNR,
  title={Kallidinogenase normalizes retinal vasopermeability in streptozotocin-induced diabetic rats: potential roles of vascular endothelial growth factor and nitric oxide.},
  author={Noriaki Kato and Yunlong Hou and Zhenhui Lu and Chunmei Lu and Hiroshi Nagano and Kiyoshi Suzuma and Hitoshi Takagi and Yukiharu Matsumoto},
  journal={European journal of pharmacology},
  year={2009},
  volume={606 1-3},
  pages={187-90}
}
We studied the suppressant effect of kallidinogenase on retinal vascular permeability and vascular endothelial growth factor (VEGF) in diabetic rats. Diabetes was induced by intravenously injecting streptozotocin (60 mg/kg body weight) dissolved in citrate buffer. Kallidinogenase (7 microg/kg/day) was injected intravenously once daily for 21 days. The retinal vascular permeability was estimated from the amount of fluorescent dye leaking into the retina after administration of fluorescein… CONTINUE READING

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