Kalirin, a multifunctional PAM COOH-terminal domain interactor protein, affects cytoskeletal organization and ACTH secretion from AtT-20 cells.

@article{Mains1999KalirinAM,
  title={Kalirin, a multifunctional PAM COOH-terminal domain interactor protein, affects cytoskeletal organization and ACTH secretion from AtT-20 cells.},
  author={Richard E Mains and M d Rowshon Alam and Re-reading Chalmers Johnson and Daniel N. Darlington and Nils B{\"a}ck and Tracey A Hand and Betty A Eipper},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 5},
  pages={2929-37}
}
The production and regulated secretion of bioactive peptides require a series of lumenal enzymes to convert inactive precursors into bioactive peptides plus several cytosolic proteins to govern granule formation, maturation, translocation, and exocytosis. Peptidylglycine alpha-amidating monooxygenase (PAM), an enzyme essential for biosynthesis of many peptides, is an integral membrane protein with trafficking information in both its lumenal and cytosolic domains. Kalirin, a PAM cytosolic domain… CONTINUE READING

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