Kalimantacin A, B, and C, novel antibiotics produced by Alcaligenes sp. YL-02632S. II. Physico-chemical properties and structure elucidation.
@article{Tokunaga1996KalimantacinAB, title={Kalimantacin A, B, and C, novel antibiotics produced by Alcaligenes sp. YL-02632S. II. Physico-chemical properties and structure elucidation.}, author={Tatsuhiro Tokunaga and Kazuma Kamigiri and Masaya Orita and Tsunehiko Nishikawa and Minoru Shimizu and Hidetoshi Kaniwa}, journal={The Journal of antibiotics}, year={1996}, volume={49 2}, pages={ 140-4 } }
Kalimantacin A, B and C are new antibiotics produced by Alcaligenes sp. YL-02632S. Their structures were elucidated to be novel long chain structure compounds containing O-carbamoyl, amide and carboxylic acid moieties based on various 2D NMR experiments and MS analysis.
16 Citations
Total Synthesis of Kalimantacin A.
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The first total synthesis of kalimantacin A is reported, in which three fragments are prepared and then united via Sonogashira and amide couplings, unlocking routes to further kalIMantacins and analogues for structure-activity relationship studies and clinical evaluation.
Isolation and purification of a new kalimantacin/batumin-related polyketide antibiotic and elucidation of its biosynthesis gene cluster.
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Biosynthesis of polyketides by trans-AT polyketide synthases.
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The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target.
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- 2010
Genome Sequence of Alcaligenes sp. Strain HPC1271
- Biology, EngineeringGenome Announcements
- 2013
ABSTRACT We report a draft genome sequence of Alcaligenes sp. strain HPC1271, which demonstrates antimicrobial activity against multidrug-resistant bacteria. Antibiotic production by Alcaligenes has…
Polyketide β-branching: diversity, mechanism and selectivity.
- Chemistry, BiologyNatural product reports
- 2020
This review covers 2008 to August 2020 and summarises the diversity of β-branch incorporation and the mechanistic details of each catalytic step, extended to discussion of polyketides containing multipleβ-branches and the selectivity exerted by the PKS to ensure β- Branching fidelity.
Carbohydrate chiral-pool approach to four enantiomerically pure 2-naphthylmethyl 3-hydroxy-2-methylbutanoates
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- 2008
Characterization of Alcaligenes faecalis strain AD15 indicating biocontrol activity against plant pathogens.
- BiologyThe Journal of general and applied microbiology
- 2013
Results indicated that the biocontrol activity of strain AD15 might be attributed to hydroxylamine, a metabolite in the culture medium, and it had the potential for biopesticide application.
Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights.
- BiologyNatural product reports
- 2017
A comprehensive list of natural products with antimicrobial activity from Gram-negative bacteria, including information on their biosynthetic origin(s) and molecular target(s), where known.
Selecting lipopeptide‐producing, Fusarium‐suppressing Bacillus spp.: Metabolomic and genomic probing of Bacillus velezensis NWUMFkBS10.5
- Medicine, BiologyMicrobiologyOpen
- 2019
The results of this study indicate that the maize rhizosphere remains a reservoir for microbial strains with unique beneficial properties and the versatile genomic potential of the best Bacillus isolate emphasizes the continued relevance of Bacillus spp.
References
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Kalimantacins A, B and C, novel antibiotics from Alcaligenes sp. YL-02632S. I. Taxonomy, fermentation, isolation and biological properties.
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The taxonomy of the producing strain, fermentation, isolation and biological activities of kalimantacins are reported and inhibit the growth of Staphylococcus aureus and S. epidermidis including multiple-drug resistant strains.
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Pseudomonic acid B, a minor antibiotic produced by Pseudomonas fluorescens, has been identified as…