Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif.

@article{Daly2006KalataBA,
  title={Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif.},
  author={Norelle L Daly and Richard J. Clark and Manuel Rey R Plan and David J. Craik},
  journal={The Biochemical journal},
  year={2006},
  volume={393 Pt 3},
  pages={
          619-26
        }
}
The cyclotides are a family of circular proteins with a range of biological activities and potential pharmaceutical and agricultural applications. The biosynthetic mechanism of cyclization is unknown and the discovery of novel sequences may assist in achieving this goal. In the present study, we have isolated a new cyclotide from Oldenlandia affinis, kalata B8, which appears to be a hybrid of the two major subfamilies (Möbius and bracelet) of currently known cyclotides. We have determined the… CONTINUE READING

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