Kaiso regulates Znf131-mediated transcriptional activation.

@article{Donaldson2010KaisoRZ,
  title={Kaiso regulates Znf131-mediated transcriptional activation.},
  author={Nickett S. Donaldson and Curtis L. Nordgaard and Christina C. Pierre and Kevin F. Kelly and Shaiya C. Robinson and Laura L Swystun and Roberto Henriquez and Monica Graham and Juliet M. Daniel},
  journal={Experimental cell research},
  year={2010},
  volume={316 10},
  pages={1692-705}
}
Kaiso is a dual-specificity POZ-ZF transcription factor that regulates gene expression by binding to sequence-specific Kaiso binding sites (KBS) or methyl-CpG dinucleotide pairs. Kaiso was first identified as a binding partner for the epithelial cell adhesion regulator p120(ctn). The p120(ctn)/Kaiso interaction is reminiscent of the beta-catenin/TCF interaction and several studies have suggested that Kaiso is a negative regulator of the Wnt/beta-catenin TCF signaling pathway. To gain further… CONTINUE READING

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Mentioned Connections BETA
Transcription, GeneticBiological process results from biological processTranscriptional Activation
Kaiso overexpression significantly decreased the Znf131-mediated transcriptional activation , and interestingly , co - expression of the Kaiso - specific interaction partner p120(ctn ) relieved Kaiso 's inhibition of Znf131-mediated transcriptional activation .
Kaiso overexpression significantly decreased the Znf131-mediated transcriptional activation , and interestingly , co - expression of the Kaiso - specific interaction partner p120(ctn ) relieved Kaiso 's inhibition of Znf131-mediated transcriptional activation .
We observed dose - dependent transcriptional activation of this artificial promoter - reporter by Znf131 in both epithelial and fibroblast cells , suggesting that Znf131 is a transcriptional activator .
In vitro studies using electrophoretic mobility shift assay ( EMSA ) demonstrated that Znf131 binds the ZBE via its zinc finger domain . Znf131
beta cateninGene product plays role in biological processSignal Transduction
The p120(ctn)/Kaiso interaction is reminiscent of the beta - catenin / TCF interaction and several studies have suggested that Kaiso is a negative regulator of the Wnt / beta - catenin TCF signaling pathway .
The p120(ctn)/Kaiso interaction is reminiscent of the beta - catenin / TCF interaction and several studies have suggested that Kaiso is a negative regulator of the Wnt / beta - catenin TCF signaling pathway .
The p120(ctn)/Kaiso interaction is reminiscent of the beta - catenin / TCF interaction and several studies have suggested that Kaiso is a negative regulator of the Wnt / beta - catenin TCF signaling pathway .
The p120(ctn)/Kaiso interaction is reminiscent of the beta - catenin / TCF interaction and several studies have suggested that Kaiso is a negative regulator of the Wnt / beta - catenin TCF signaling pathway .
Transcription CoactivatorGene product plays role in biological processTranscriptional Activation
We observed dose - dependent transcriptional activation of this artificial promoter - reporter by Znf131 in both epithelial and fibroblast cells , suggesting that Znf131 is a transcriptional activator .
In vitro studies using electrophoretic mobility shift assay ( EMSA ) demonstrated that Znf131 binds the ZBE via its zinc finger domain . Znf131
CateninsIs biochemical function of gene productbeta catenin
The p120(ctn)/Kaiso interaction is reminiscent of the beta - catenin / TCF interaction and several studies have suggested that Kaiso is a negative regulator of the Wnt / beta - catenin TCF signaling pathway .
The p120(ctn)/Kaiso interaction is reminiscent of the beta - catenin / TCF interaction and several studies have suggested that Kaiso is a negative regulator of the Wnt / beta - catenin TCF signaling pathway .
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