Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors

@article{Ferkany1982KainicAS,
  title={Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors},
  author={John W. Ferkany and Robert C. Zaczek and Joseph T Coyle},
  journal={Nature},
  year={1982},
  volume={298},
  pages={757-759}
}
Kainic acid (KA), a conformationally restricted analogue of glutamic acid, exhibits potent neuroexcitatory1 and neurotoxic properties2. The mechanism of the neurotoxicity of KA, however, seems to be complex and indirect because in many brain areas neuronal vulnerability requires the integrity of excitatory afferents3–6. Nevertheless, neurophysiological… CONTINUE READING