Kainic acid induces apoptosis in neurons.

  title={Kainic acid induces apoptosis in neurons.},
  author={N A Simonian and Reina L. Getz and J C Leveque and Christine Konradi and Joseph T Coyle},
  volume={75 4},
Growing evidence suggests that non-N-methyl-D-aspartate receptor activation may contribute to neuronal death in both acute and chronic neurological diseases. The intracellular processes that mediate this form of neuronal death are poorly understood. We have previously characterized a model of kainic acid neurotoxicity using cerebellar granule cell neurons in vitro and we sought to determine the mechanism of kainic acid-induced neuronal degeneration. We found DNA laddering by agarose gel… CONTINUE READING


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