Kainic acid-induced seizures and brain damage in the rat: role of calcium homeostasis.

@article{Berg1995KainicAS,
  title={Kainic acid-induced seizures and brain damage in the rat: role of calcium homeostasis.},
  author={Marita Berg and Torben Bruhn and A. M. Frandsen and Arne Schousboe and Nils Henrik Diemer},
  journal={Journal of neuroscience research},
  year={1995},
  volume={40 5},
  pages={641-6}
}
Seizure activity induced by kainic acid (KA) and subsequent neuronal death are thought to be associated with an increase in cytoplasmic free calcium ([Ca2+]i) and can be prevented by N-methyl-D-aspartate (NMDA) antagonists. In addition to influx through receptor operated Ca2+ channels the increase in [Ca2+]i may be the result of an increased influx through voltage-operated calcium channels and/or release from intracellular deposits. It was therefore investigated whether compounds other than… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2008
View 4 Excerpts
Highly Influenced

Excitotoxic and excitoprotective mechanisms

NeuroMolecular Medicine • 2007
View 2 Excerpts

Similar Papers

Loading similar papers…