Kainic acid induced limbic seizures: metabolic, behavioral, electroencephalographic and neuropathological correlates

@article{Lothman1981KainicAI,
  title={Kainic acid induced limbic seizures: metabolic, behavioral, electroencephalographic and neuropathological correlates},
  author={E W Lothman and Robert C. Collins},
  journal={Brain Research},
  year={1981},
  volume={218},
  pages={299-318}
}
Increasing amounts (0.3-12 mg/kg) of kainic acid (KA) were given intravenously to rats and behavioral, electrographic, 2-deoxyglucose autoradiographic and neuropathologic responses were studied. A dose of 12 mg/kg kainic acid caused a stereotyped sequence of staring spells, wet dog shakes, automatisms mild limbic convulsions and severe limbic convulsions (rearing, bilateral upper extremity clonus, falling and salivation) that developed over l-2 h. Smaller doses showed different thresholds for… CONTINUE READING

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