Kainic acid-induced generalized seizures alter the regional hippocampal expression of the rat Kv4.2 potassium channel gene

@article{Francis1997KainicAG,
  title={Kainic acid-induced generalized seizures alter the regional hippocampal expression of the rat Kv4.2 potassium channel gene},
  author={Joseph Francis and Denis G M Jugloff and N S Mingo and Mark C. Wallace and James H. Eubanks},
  journal={Neuroscience Letters},
  year={1997},
  volume={232},
  pages={91-94}
}
Potassium channels play a key role in the regulation of membrane excitability. We investigated the gene expression response of the Kv4.2 subtype of potassium channel, in the rat hippocampus, to a brief (5 min) episode of kainic acid-induced seizures. Our results demonstrate that Kv4.2 expression is reduced in the granule cell layer of the dentate gyrus at 3 h post-seizure, while no significant changes in expression are observed in other hippocampal subfields. At 6 h post-challenge, expression… CONTINUE READING

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