Kainic acid dose affects delayed cell death mechanism after status epilepticus.

@article{Tokuhara2007KainicAD,
  title={Kainic acid dose affects delayed cell death mechanism after status epilepticus.},
  author={Daisuke Tokuhara and Satoru Sakuma and Hideji Hattori and Osamu Matsuoka and Tsunekazu Yamano},
  journal={Brain & development},
  year={2007},
  volume={29 1},
  pages={2-8}
}
Kainic acid (KA)-induced status epilepticus (SE) produces hippocampal neuronal death, which varies from necrosis to apoptosis or programmed cell death (PCD). We examined whether the type of neuronal death was dependent on KA dose. Adult rats were induced SE by intraperitoneal injection of KA at 9 mg/kg (K9) or 12 mg/kg (K12). Hippocampal neuronal death was assessed by TUNEL staining, electron microscopy, and Western blotting of caspase-3 on days 1, 3 and 7 after SE induction. K12 rats showed… CONTINUE READING
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