Kainic acid derivatives as excitants of lateral geniculate relay neurons.


The activities of kainic acid and its derivatives alpha-ketokainic acid and dihydrokainic acid have been compared with L-glutamic acid as excitants of identified central neurons. The results are consistent with the view that the high activity of kainate is associated with unsaturation in the isopropylene side-chain. It is suggested that a reduction in the… (More)


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