Kainic acid‐induced status epilepticus alters GABAA receptor subunit mRNA and protein expression in the developing rat hippocampus

@article{Laurn2005KainicAS,
  title={Kainic acid‐induced status epilepticus alters GABAA receptor subunit mRNA and protein expression in the developing rat hippocampus},
  author={H. Laur{\'e}n and F. L{\'o}pez-Pic{\'o}n and E. Korpi and I. Holopainen},
  journal={Journal of Neurochemistry},
  year={2005},
  volume={94}
}
Kainic acid‐induced status epilepticus leads to structural and functional changes in inhibitory GABAA receptors in the adult rat hippocampus, but whether similar changes occur in the developing rat is not known. We have used in situ hybridization to study status epilepticus‐induced changes in the GABAAα1–α5, β1–β3, γ1 and γ2 subunit mRNA expression in the hippocampus of 9‐day‐old rats during 1 week after the treatment. Immunocytochemistry was applied to detect the α1, α2 and β3 subunit proteins… Expand
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