Kainate receptors exhibit differential sensitivities to (S)-5-iodowillardiine.

@article{Swanson1998KainateRE,
  title={Kainate receptors exhibit differential sensitivities to (S)-5-iodowillardiine.},
  author={Geoffrey T Swanson and Tim A. Green and Stephen F. Heinemann},
  journal={Molecular pharmacology},
  year={1998},
  volume={53 5},
  pages={942-9}
}
Characterization of the role of kainate receptors in excitatory synaptic transmission has been hampered by a lack of subtype-selective pharmacological agents. (S)-5-Iodowillardiine (IW), an analog of willardiine [(S)-1-(2-amino-2-carboxyethyl)pyrimidine-2,4-dione], a heterocyclic amino acid found in Acacia and Mimosa seeds, was previously shown to be highly potent on native kainate receptors in dorsal root ganglion neurons. We examined the responses evoked by IW from recombinant homomeric and… CONTINUE READING

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