Kainate receptors and synaptic transmission

@article{Huettner2003KainateRA,
  title={Kainate receptors and synaptic transmission},
  author={James E Huettner},
  journal={Progress in Neurobiology},
  year={2003},
  volume={70},
  pages={387-407}
}
The physiological role of kainate receptors in the amygdala
TLDR
Findings have suggested a prominent role of GLUk5-containing kainate receptors in the regulation of neuronal excitability in the amygdala.
Kainate Receptors Modulating Glutamate Release in the Cerebellum
TLDR
Roles and mechanisms involved in the modulation of glutamate release in the cerebellum at parallel fibers (PF)-Purkinje Cells (PuC) synapses are reviewed.
Presynaptic kainate receptor-mediated bidirectional modulatory actions: Mechanisms
In the developing hippocampus kainate receptors control the release of GABA from mossy fiber terminals via a metabotropic type of action.
TLDR
GluK1 KARs dynamically regulate the direction of spike-time dependent plasticity, a particular form of Hebbian type of learning which consists in bidirectional modifications in synaptic strength according to the temporal order of pre and postsynaptic spiking.
Presynaptic kainate receptor facilitation of glutamate release involves protein kinase A in the rat hippocampus
TLDR
It is concluded that kainate receptors present at presynaptic terminals in the rat hippocampus mediate the facilitation of glutamate release through a mechanism involving the activation of an adenylyl cyclase–second messenger cAMP–protein kinase A signalling cascade.
Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex.
TLDR
Patch-clamp recordings in genetically modified mice show that postsynaptic KA receptors contribute to fast synaptic transmission in pyramidal neurons in the anterior cingulate cortex (ACC), a forebrain region critical for higher-order cognitive brain functions such as memory and mental disorders.
Profound regulation of neonatal CA1 rat hippocampal GABAergic transmission by functionally distinct kainate receptor populations
TLDR
The data demonstrate that kainate receptors profoundly regulate neonatal CA1 GABAergic circuitry by two distinct opposing mechanisms, and indicate that these two effects are mediated by functionally distinct populations of receptors.
Localization and functions of kainate receptors in the basal ganglia.
TLDR
There is further evidence supporting that these two pathways are also involved in the modulation of GABA release in specific basal ganglia nuclei.
Kainate Receptors Are the Key to Understanding Synaptic Plasticity, Learning and Memory (Review)
TLDR
The present report reviews the major mechanisms of ionotropic and metabotropic activation of kainate receptors involved in the regulation of synaptic transmission, plasticity, learning and memory.
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References

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The synaptic activation of kainate receptors
TLDR
It is demonstrated that high-frequency stimulation of mossy fibres in rat hippocampal slices, in the presence of the highly selective AMPA receptor antagonist GYKI 53655, plus NMDA- and GABA-receptor antagonists, activates an inward current in CA3 neurons that has a pharmacology typical of kainate receptors.
Developmental and activity- dependent regulation of kainate receptors at thalamocortical synapses
TLDR
It is shown that developing thalamocortical synapses express postsynaptic kainate receptors as well as AMPA receptors; however, the two receptor subtypes do not co-localize.
Kainate-receptor-mediated sensory synaptic transmission in mammalian spinal cord
TLDR
It is shown that high-intensity single-shock stimulation of primary afferent sensory fibres produces a fast, kainate-receptor-mediated EPSC in the superficial dorsal horn of the spinal cord, which contributes to transmission of somatosensory inputs from the periphery to the brain.
Synaptically released glutamate reduces gamma-aminobutyric acid (GABA)ergic inhibition in the hippocampus via kainate receptors.
TLDR
The net kainate receptor-mediated effect of synaptically released glutamate is to reduce monosynaptic inhibition, which may constitute an important target for anticonvulsant drug development.
Loss of Kainate Receptor-Mediated Heterosynaptic Facilitation of Mossy-Fiber Synapses in KA2−/− Mice
TLDR
The results identify the KA2 subunit as a determinant of kainate receptor function at presynaptic and postsynaptic mossy-fiber kainates receptors.
Kainate Receptors Depress Excitatory Synaptic Transmission at CA3→CA1 Synapses in the Hippocampus via a Direct Presynaptic Action
TLDR
The results suggest that KA receptor activation depresses synaptic transmission at this synapse via a direct, presynaptic, metabotropic action.
Two populations of kainate receptors with separate signaling mechanisms in hippocampal interneurons.
TLDR
It is shown that both effects, membrane depolarization and the reduction of inhibitory potentials, can be dissociated by several means, particularly by the natural agonist of kainate receptors, glutamate.
Kainate acts at presynaptic receptors to increase GABA release from hypothalamic neurons.
TLDR
In the hypothalamus where a much higher number of GABAergic cells exist, kainate-mediated activation of transmitter release from inhibitory neurons may reduce the level of neuronal activity in the postsynaptic cell.
Presynaptic Kainate Receptors Regulate Spinal Sensory Transmission
TLDR
It is shown that kainate, applied at low micromolar concentrations in the presence of the AMPA-selective antagonist (RS)-4-(4-aminophenyl)-1,2-dihydro-1-methyl-2-propyl-carbamoyl-6,7-methylenedioxyphthalazine, suppressed spontaneous NMDA receptor-mediated EPSCs in cultures of spinal dorsal horn neurons.
Ionotropic Glutamate Receptors in the CNS
TLDR
The Glutamate Transporter Dysfunction and Neuronal Death and NMDA Recepor Antagonists and Their Potential as Neuroprotective Agents are studied.
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