Kainate receptor pore‐forming and auxiliary subunits regulate channel block by a novel mechanism

@inproceedings{Brown2016KainateRP,
  title={Kainate receptor pore‐forming and auxiliary subunits regulate channel block by a novel mechanism},
  author={Patricia M G E Brown and Mark R. P. Aurousseau and Maria Musgaard and Philip C. Biggin and Derek Bowie},
  booktitle={The Journal of physiology},
  year={2016}
}
KEY POINTS Kainate receptor heteromerization and auxiliary subunits, Neto1 and Neto2, attenuate polyamine ion-channel block by facilitating blocker permeation. Relief of polyamine block in GluK2/GluK5 heteromers results from a key proline residue that produces architectural changes in the channel pore α-helical region. Auxiliary subunits exert an additive effect to heteromerization, and thus relief of polyamine block is due to a different mechanism. Our findings have broad implications for work… CONTINUE READING
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