Kainate receptor-mediated presynaptic inhibition converges with presynaptic inhibition mediated by Group II mGluRs and long-term depression at the hippocampal mossy fiber-CA3 synapse

@article{NegreteDaz2007KainateRP,
  title={Kainate receptor-mediated presynaptic inhibition converges with presynaptic inhibition mediated by Group II mGluRs and long-term depression at the hippocampal mossy fiber-CA3 synapse},
  author={Jos{\'e} Vicente Negrete-D{\'i}az and Talvinder S. Sihra and Jos{\'e} Mar{\'i}a Delgado-Garc{\'i}a and Antonio Rodr{\'i}guez-Moreno},
  journal={Journal of Neural Transmission},
  year={2007},
  volume={114},
  pages={1425-1431}
}
Kainate receptors (KARs) effect depression of glutamate release at hippocampal mossy fiber-CA3 (MF-CA3) synapses by a metabotropic action involving adenylyl cyclase (AC) inhibition, cAMP reduction, and diminished protein kinase A (PKA) activation. Using hippocampal slices, we show here that KAR activation interferes with the depression of glutamate release produced by Group II metabotropic glutamate receptor stimulation and low frequency stimulation (LFS)-induced long-term depression (LTD… CONTINUE READING

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