Kainate Receptors in Health and Disease

  title={Kainate Receptors in Health and Disease},
  author={Juan Lerma and Joana M. Marques},

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Physiopathology of kainate receptors in epilepsy.
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This review summarizes the current data about the mechanism and role of pre-mRNA editing of KAR subunits in the mammalian brain and proposes a perspective of future investigations.


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Although significant progress has been made toward the elucidation of their importance for brain function, kainate receptors remain largely an enigma and some new roads that should be explored to obtain a deeper understanding of this young, but intriguing, class of proteins are proposed.
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Subunit specific antagonists of KARs have therapeutic potential in neurodegenerative and psychiatric diseases as well as in epilepsy and pain.
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Metabotropic signaling by kainate receptors
It is now clear that this dual signaling underlies the diverse functions of Kars and defining this metabotropic component of the signaling system operated by KARs will be necessary to understand the physiological contributions of glutamate receptors.
Subcellular localization and trafficking of kainate receptors.
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The findings related to the roles of KARs in short- and long-term forms of plasticity, primarily in the hippocampus, where KAR function and synaptic plasticity have received avid attention are summarized.
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