Kainate GluR5 receptor subtype mediates the nociceptive response to formalin in the rat.

@article{Simmons1998KainateGR,
  title={Kainate GluR5 receptor subtype mediates the nociceptive response to formalin in the rat.},
  author={Rosa Maria A Simmons and Dominic L Li and Ken H. Hoo and Michelle Deverill and Paul L Ornstein and Smriti Iyengar},
  journal={Neuropharmacology},
  year={1998},
  volume={37 1},
  pages={25-36}
}
In order to study the roles of the AMPA and kainate subtypes of non-NMDA glutamate receptors in the processing of persistent nociceptive information, compounds with varying activities at these receptors were examined for effects on the formalin-induced paw-licking behavior in rats. The selective AMPA antagonist, LY300164 and the mixed AMPA/kainate antagonist, NBQX, were compared for their effects on formalin-induced pain behavior. NBQX (3, 10, 20 mg/kg, i.p.), caused antinociception as well as… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 55 extracted citations

Deletion of the glutamate receptor 5 subunit of kainate receptors affects the development of morphine tolerance.

The Journal of pharmacology and experimental therapeutics • 2009
View 10 Excerpts
Highly Influenced

Generation and analysis of GluR5(Q636R) kainate receptor mutant mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1999
View 5 Excerpts
Highly Influenced

Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2005
View 6 Excerpts
Highly Influenced

Divergent pharmacological activity of novel marine-derived excitatory amino acids on glutamate receptors.

The Journal of pharmacology and experimental therapeutics • 2005
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…