Kahalalide F Induces Necrosis-Like Cell Death that Involves Depletion of ErbB3 and Inhibition of Akt Signaling

@article{Janmaat2005KahalalideFI,
  title={Kahalalide F Induces Necrosis-Like Cell Death that Involves Depletion of ErbB3 and Inhibition of Akt Signaling},
  author={Maarten L. Janmaat and Jose Antonio Rodriguez and Jos{\'e} Mar{\'i}a Jimeno and Frank A. E. Kruyt and Giuseppe Giaccone},
  journal={Molecular Pharmacology},
  year={2005},
  volume={68},
  pages={502 - 510}
}
Kahalalide F (KF) is a novel marine-derived antitumor agent that is currently undergoing phase II clinical trials. The mechanism of action of KF is not well understood. In line with previous reports, we show that KF caused rapid and potent cytotoxicity in the breast cancer cell lines SKBR3 and BT474, characterized by cytoplasmic swelling and DNA clumping. Several markers of caspase-dependent apoptosis, such as phosphatidyl-serine externalization, cytochrome c release, and caspase-3 and poly… 
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