Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells.

@article{Surez2003KahalalideFA,
  title={Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells.},
  author={Yajaira Su{\'a}rez and Laura Gonz{\'a}lez and Ana Cuadrado and Maite Berciano and Miguel Lafarga and Alberto Mu{\~n}oz},
  journal={Molecular cancer therapeutics},
  year={2003},
  volume={2 9},
  pages={863-72}
}
Kahalalide F (KF) is a novel antitumor drug of marine origin under clinical investigation. KF showed a potent cytotoxic activity against a panel of human prostate and breast cancer cell lines, with IC(50) ranging from 0.07 micro M (PC3) to 0.28 micro M (DU145, LNCaP, SKBR-3, BT474, MCF7). Importantly, nontumor human cells (MCF10A, HUVEC, HMEC-1, IMR90) were 5-40 times less sensitive to the drug (IC(50) = 1.6-3.1 micro M). KF cytotoxicity did not correlate with the expression level of the… CONTINUE READING