Kaempferol regulates MAPKs and NF-κB signaling pathways to attenuate LPS-induced acute lung injury in mice.

@article{Chen2012KaempferolRM,
  title={Kaempferol regulates MAPKs and NF-κB signaling pathways to attenuate LPS-induced acute lung injury in mice.},
  author={Xiaojun Chen and Xiaofeng Yang and Tianjiao Liu and Mingfeng Guan and Xiangru Feng and Wei Dong and Xiao Chu and Jing Liu and Xiuli Tian and Xinxin Ci and Hongyu Li and Jingyuan Wei and Yanhong Deng and Xuming Deng and Gefu Chi and Zhiliang Sun},
  journal={International immunopharmacology},
  year={2012},
  volume={14 2},
  pages={209-16}
}
Recent studies show that mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-κB) signaling pathways are two pivotal roles contributing to the development of lipopolysaccharide (LPS)-induced acute lung injury (ALI). The present study aimed to investigate the protective effect of kaempferol (Kae), a naturally occurring flavonoid compound, on ALI and explore its possible mechanisms. Male BALB/c mice with ALI, induced by intranasal instillation of LPS, were treated or not with… CONTINUE READING

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