Kaempferol inhibits IL-4-induced STAT6 activation by specifically targeting JAK3.

  title={Kaempferol inhibits IL-4-induced STAT6 activation by specifically targeting JAK3.},
  author={J. Rodriguez Cortes and Moises Perez-G and Maria Dolores Gadea Rivas and Jos{\'e} Louis Zamorano},
  journal={Journal of immunology},
  volume={179 6},
IL-4 is involved in several human diseases including allergies, autoimmunity, and cancer. Its effects are mainly mediated through the transcription factor STAT6. Therefore, investigation of compounds that regulate STAT6 activation is of great interest for these diseases. Natural polyphenols are compounds reported to have therapeutic properties in diseases involving IL-4 and STAT6. The aim of this study was to investigate the effect of these compounds in the activation of this transcription… CONTINUE READING


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