Kaempferol induced inhibition of HL-60 cell growth results from a heterogeneous response, dominated by cell cycle alterations.

@article{Bestwick2007KaempferolII,
  title={Kaempferol induced inhibition of HL-60 cell growth results from a heterogeneous response, dominated by cell cycle alterations.},
  author={Charles Stuart Bestwick and Lesley Milne and Susan J. Duthie},
  journal={Chemico-biological interactions},
  year={2007},
  volume={170 2},
  pages={76-85}
}
Dietary flavonoids may be exploitable as chemotherapeutics and preventatives for critical health conditions, including cancer. Antiproliferative effects are commonly ascribed to such compounds but ambiguity exists as to the principal mechanism of action and the universal benefit of exposure, particularly at high concentrations. Here, we identify heterogeneous responses within HL-60 promyelocytic leukaemia cells that explain contradictions in the reported origin of the antiproliferative action… CONTINUE READING

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